Cutaneous lymphocyte antigen expression loss and PD1 positivity in early cutaneous lesions of rapidly progressive mycosis fungoides
نویسندگان
چکیده
KEY CLINICAL MESSAGE It's important to assess cases both clinically and pathologically for factors potentially predictive of an aggressive clinical course. We concluded that the relative immunosuppressive effects of PD1 may contribute to tumor progression while the lack of staining for cutaneous lymphocyte antigen may be an additional factor facilitating distant extracutaneous migration.
منابع مشابه
CD7 Expression in Differentiating Mycosis Fungoides from Benign Cutaneous Lymphocytic Infiltrates
Background: Diagnosis of the early phase of mycosis fungoides (MF) is sometimes difficult. Loss of CD7 expression is considered a distinguishing characteristic of MF. The aim of this study was to determine the range of CD7 expression in MF and compare the results with benign inflammatory dermatosis and equivocal cases of possible MF. Methods: During a period of 30 months, we examined 15 patient...
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Mycosis fungoides (MF) is the most common form of cutaneous T-cell lymphoma. Persistent antigenic stimulation has been claimed to play a role in the development of this malignancy. We aimed to show the role of sulfur mustard in the pathogenesis of MF. A 45-year-old man with MF is introduced herein. He was a victim of chemical exposure in 1987 during the Iran–Iraq war. He developed skin lesions ...
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عنوان ژورنال:
دوره 2 شماره
صفحات -
تاریخ انتشار 2014